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Zika virus

This article is about the virus. For the disease, see Zika fever. For the recent outbreak, see 2015–2016 Zika virus epidemic.

Zika virus (ZIKV; pronounced or) is a member of the virus family Flaviviridae. It is spread by daytime-active Aedes mosquitoes, such as A. aegypti and A. albopictus. Its name comes from the Ziika Forest of Uganda, where the virus was first isolated in 1947. Zika virus shares a genus with the dengue, yellow fever, Japanese encephalitis, and West Nile viruses. Since the 1950s, it has been known to occur within a narrow equatorial belt from Africa to Asia. From 2007 to 2016[update], the virus spread eastward, across the Pacific Ocean to the Americas, leading to the 2015–2016 Zika virus epidemic.

Zika virus
Electron micrograph of Zika virus. Virus particles (digitally colored purple) are 40 nm in diameter, with an outer envelope and a dense inner core.
Zika virus capsid model, colored by chains, PDB entry5ire
Virus classification
(unranked): Virus
Realm: Riboviria
Kingdom: Orthornavirae
Phylum: Kitrinoviricota
Class: Flasuviricetes
Order: Amarillovirales
Family: Flaviviridae
Genus: Flavivirus
Species:
Zika virus

The infection, known as Zika fever or Zika virus disease, often causes no or only mild symptoms, similar to a very mild form of dengue fever. While there is no specific treatment, paracetamol (acetaminophen) and rest may help with the symptoms. As of April 2019, no vaccines have been approved for clinical use, however a number of vaccines are currently in clinical trials. Zika can spread from a pregnant woman to her baby. This can result in microcephaly, severe brain malformations, and other birth defects. Zika infections in adults may result rarely in Guillain–Barré syndrome.

In January 2016, the United States Centers for Disease Control and Prevention (CDC) issued travel guidance on affected countries, including the use of enhanced precautions, and guidelines for pregnant women including considering postponing travel. Other governments or health agencies also issued similar travel warnings, while Colombia, the Dominican Republic, Puerto Rico, Ecuador, El Salvador, and Jamaica advised women to postpone getting pregnant until more is known about the risks.

Contents

Zika virus belongs to the family Flaviviridae and the genus Flavivirus, thus is related to the dengue, yellow fever, Japanese encephalitis, and West Nile viruses. Like other flaviviruses, Zika virus is enveloped and icosahedral and has a nonsegmented, single-stranded, 10 kilobase, positive-sense RNA genome. It is most closely related to the Spondweni virus and is one of the two known viruses in the Spondweni virus clade.

Cross-section of Zika virus, showing the viral envelope composed of envelope proteins (red) and membrane proteins (purple) embedded in the lipid membrane (white): The capsid proteins (orange) are shown interacting with the RNA genome (yellow) at the center of the virus.

A positive-sense RNA genome can be directly translated into viral proteins. As in other flaviviruses, such as the similarly sized West Nile virus, the RNA genome encodes seven nonstructural proteins and three structural proteins in the form of a single polyprotein (Q32ZE1). One of the structural proteins encapsulates the virus. This protein is the flavivirus envelope glycoprotein, that binds to the endosomal membrane of the host cell to initiate endocytosis. The RNA genome forms a nucleocapsid along with copies of the 12-kDa capsid protein. The nucleocapsid, in turn, is enveloped within a host-derived membrane modified with two viral glycoproteins. Viral genome replication depends on the making of double-stranded RNA from the single-stranded, positive-sense RNA (ssRNA(+)) genome followed by transcription and replication to provide viral mRNAs and new ssRNA(+) genomes. The 3’ untranslated region (3’ UTR) of Zika contains highly structured RNAs that stall the processivity of the XRN1 exoribonuclease leading to production of the subgenomic flavivirus RNA (sfRNA).

A longitudinal study shows that 6 hours after cells are infected with Zika virus, the vacuoles and mitochondria in the cells begin to swell. This swelling becomes so severe, it results in cell death, also known as paraptosis. This form of programmed cell death requires gene expression. IFITM3 is a trans-membrane protein in a cell that is able to protect it from viral infection by blocking virus attachment. Cells are most susceptible to Zika infection when levels of IFITM3 are low. Once the cell has been infected, the virus restructures the endoplasmic reticulum, forming the large vacuoles, resulting in cell death.

There are two Zika lineages: the African lineage and the Asian lineage. Phylogenetic studies indicate that the virus spreading in the Americas is 89% identical to African genotypes, but is most closely related to the Asian strain that circulated in French Polynesia during the 2013–2014 outbreak.

The Asian strain appears to have first evolved around 1928.

The vertebrate hosts of the virus were primarily monkeys in a so-called enzootic mosquito-monkey-mosquito cycle, with only occasional transmission to humans. Before the current pandemic began in 2007, Zika "rarely caused recognized 'spillover' infections in humans, even in highly enzootic areas". Infrequently, however, other arboviruses have become established as a human disease and spread in a mosquito–human–mosquito cycle, like the yellow fever virus and the dengue fever virus (both flaviviruses), and the chikungunya virus (a togavirus). Though the reason for the pandemic is unknown, dengue, a related arbovirus that infects the same species of mosquito vectors, is known in particular to be intensified by urbanization and globalization. Zika is primarily spread by Aedes aegypti mosquitoes, and can also be transmitted through sexual contact or blood transfusions. The basic reproduction number (R0, a measure of transmissibility) of Zika virus has been estimated to be between 1.4 and 6.6 .

In 2015, news reports drew attention to the rapid spread of Zika in Latin America and the Caribbean. At that time, the Pan American Health Organization published a list of countries and territories that experienced "local Zika virus transmission" comprising Barbados, Bolivia, Brazil, Colombia, the Dominican Republic, Ecuador, El Salvador, French Guiana, Guadeloupe, Guatemala, Guyana, Haiti, Honduras, Martinique, Mexico, Panama, Paraguay, Puerto Rico, Saint Martin, Suriname, and Venezuela. By August 2016, more than 50 countries had experienced active (local) transmission of Zika virus.

Mosquito

Global Aedes aegypti predicted distribution. The map depicts the probability of occurrence (blue=none, red=highest occurrence).

Zika is primarily spread by the female Aedes aegypti mosquito, which is active mostly in the daytime. The mosquitos must feed on blood to lay eggs.: 2 The virus has also been isolated from a number of arboreal mosquito species in the genus Aedes, such as A. africanus, A. apicoargenteus, A. furcifer, A. hensilli, A. luteocephalus, and A. vittatus, with an extrinsic incubation period in mosquitoes around 10 days.

The true extent of the vectors is still unknown. Zika has been detected in many more species of Aedes, along with Anopheles coustani, Mansonia uniformis, and Culex perfuscus, although this alone does not incriminate them as vectors. To detect the presence of the virus usually requires genetic material to be analysed in a lab using the technique RT-PCR. A much cheaper and faster method involves shining a light at the head and thorax of the mosquito, and detecting chemical compounds characteristic of the virus using near-infrared spectroscopy.

Transmission by A. albopictus, the tiger mosquito, was reported from a 2007 urban outbreak in Gabon, where it had newly invaded the country and become the primary vector for the concomitant chikungunya and dengue virus outbreaks. New outbreaks can occur if a person carrying the virus travels to another region where A. albopictus is common.

The potential societal risk of Zika can be delimited by the distribution of the mosquito species that transmit it. The global distribution of the most cited carrier of Zika, A. aegypti, is expanding due to global trade and travel. A. aegypti distribution is now the most extensive ever recorded – on parts of all continents except Antarctica, including North America and even the European periphery (Madeira, the Netherlands, and the northeastern Black Sea coast). A mosquito population capable of carrying Zika has been found in a Capitol Hill neighborhood of Washington, DC, and genetic evidence suggests they survived at least four consecutive winters in the region. The study authors conclude that mosquitos are adapting for persistence in a northern climate. Zika virus appears to be contagious via mosquitoes for around a week after infection. The virus is thought to be infectious for a longer period of time after infection (at least 2 weeks) when transmitted via semen.

Research into its ecological niche suggests that Zika may be influenced to a greater degree by changes in precipitation and temperature than dengue, making it more likely to be confined to tropical areas. However, rising global temperatures would allow for the disease vector to expand their range further north, allowing Zika to follow.

Production of sfRNA by Zika has been shown to be important for efficient virus transmission by A. aegypti mosquitoes.

Sexual

Zika can be transmitted from men and women to their sexual partners; most known cases involve transmission from symptomatic men to women. As of April 2016, sexual transmission of Zika has been documented in six countries – Argentina, Australia, France, Italy, New Zealand, and the United States – during the 2015 outbreak. ZIKV can persist in semen for several months, with viral RNA detected up to one year. The virus replicates in the human testis, where it infects several cell types including testicular macrophages, peritubular cells and germ cells, the spermatozoa precursors. Semen parameters can be altered in patients for several weeks post-symptoms onset, and spermatozoa can be infectious. Since October 2016, the CDC has advised men who have traveled to an area with Zika should use condoms or not have sex for at least six months after their return as the virus is still transmissible even if symptoms never develop.

Pregnancy

Zika virus can spread by vertical (or "mother-to-child") transmission, during pregnancy or at delivery. An infection during pregnancy has been linked to changes in neuronal development of the unborn child. Severe progressions of infection have been linked to the development of microcephaly in the unborn child, while mild infections potentially can lead to neurocognitive disorders later in life. Congenital brain abnormalities other than microcephaly have also been reported after a Zika outbreak. Studies in mice have suggested that maternal immunity to dengue virus may enhance fetal infection with Zika, worsen the microcephaly phenotype and/or enhance damage during pregnancy, but it is unknown whether this occurs in humans.

Blood transfusion

As of April 2016[update], two cases of Zika transmission through blood transfusions have been reported globally, both from Brazil, after which the US Food and Drug Administration (FDA) recommended screening blood donors and deferring high-risk donors for 4 weeks. A potential risk had been suspected based on a blood-donor screening study during the French Polynesian Zika outbreak, in which 2.8% (42) of donors from November 2013 and February 2014 tested positive for Zika RNA and were all asymptomatic at the time of blood donation. Eleven of the positive donors reported symptoms of Zika fever after their donation, but only three of 34 samples grew in culture.

Zika virus replicates in the mosquito's midgut epithelial cells and then its salivary gland cells. After 5–10 days, the virus can be found in the mosquito's saliva. If the mosquito's saliva is inoculated into human skin, the virus can infect epidermal keratinocytes, skin fibroblasts in the skin and the Langerhans cells. The pathogenesis of the virus is hypothesized to continue with a spread to lymph nodes and the bloodstream. Flaviviruses replicate in the cytoplasm, but Zika antigens have been found in infected cell nuclei.

The viral protein numbered NS4A can lead to small head size (microcephaly) because it disrupts brain growth by hijacking a pathway which regulates growth of new neurons. In fruit flies, both NS4A and the neighboring NS4B restrict eye growth.

Main article: Zika fever
Rash on an arm due to Zika

Zika fever (also known as Zika virus disease) is an illness caused by Zika virus. Most cases have no symptoms, but when present they are usually mild and can resemble dengue fever. Symptoms may include fever, red eyes, joint pain, headache, and a maculopapular rash. Symptoms generally last less than seven days. It has not caused any reported deaths during the initial infection. Infection during pregnancy causes microcephaly and other brain malformations in some babies. Infection in adults has been linked to Guillain–Barré syndrome (GBS) and Zika virus has been shown to infect human Schwann cells.

Diagnosis is by testing the blood, urine, or saliva for the presence of Zika virus RNA when the person is sick. In 2019, an improved diagnostic test, based on research from Washington University in St. Louis, that detects Zika infection in serum was granted market authorization by the FDA.

Prevention involves decreasing mosquito bites in areas where the disease occurs, and proper use of condoms. Efforts to prevent bites include the use of DEET or picaridin - based insect repellent, covering much of the body with clothing, mosquito nets, and getting rid of standing water where mosquitoes reproduce. There is no vaccine. Health officials recommended that women in areas affected by the 2015–2016 Zika outbreak consider putting off pregnancy and that pregnant women not travel to these areas. While no specific treatment exists, paracetamol (acetaminophen) and rest may help with the symptoms. Admission to a hospital is rarely necessary.

Vaccine development

Main article: Zika virus vaccine

The World Health Organization has suggested that priority should be to develop inactivated vaccines and other nonlive vaccines, which are safe to use in pregnant women.

As of March 2016[update], 18 companies and institutions were developing vaccines against Zika, but they state a vaccine is unlikely to be widely available for about 10 years.

In June 2016, the FDA granted the first approval for a human clinical trial for a Zika vaccine. In March 2017, a DNA vaccine was approved for phase-2 clinical trials. This vaccine consists of a small, circular piece of DNA, known as a plasmid, that expresses the genes for the Zika virus envelope proteins. As the vaccine does not contain the full sequence of the virus, it cannot cause infection. As of April 2017, both subunit and inactivated vaccines have entered clinical trials.

Countries that have past or current evidence of Zika transmission (as of January 2016)
Spread of Zika
Spread of Zika in Africa and Asia, based on molecular sequence data.

Virus isolation in monkeys and mosquitoes, 1947

The virus was first isolated in April 1947 from a rhesus macaque monkey placed in a cage in the Ziika Forest of Uganda, near Lake Victoria, by the scientists of the Yellow Fever Research Institute. A second isolation from the mosquito A. africanus followed at the same site in January 1948. When the monkey developed a fever, researchers isolated from its serum a "filterable transmissible agent" which was named Zika in 1948.

First evidence of human infection, 1952

Zika was first known to infect humans from the results of a serological survey in Uganda, published in 1952. Of 99 human blood samples tested, 6.1% had neutralizing antibodies. As part of a 1954 outbreak investigation of jaundice suspected to be yellow fever, researchers reported isolation of the virus from a patient, but the pathogen was later shown to be the closely related Spondweni virus. Spondweni was also determined to be the cause of a self-inflicted infection in a researcher reported in 1956.

Spread in equatorial Africa and to Asia, 1951–2016

Subsequent serological studies in several African and Asian countries indicated the virus had been widespread within human populations in these regions. The first true case of human infection was identified by Simpson in 1964, who was himself infected while isolating the virus from mosquitoes. From then until 2007, there were only 13 further confirmed human cases of Zika infection from Africa and Southeast Asia. A study published in 2017 showed that the Zika virus, despite only a few cases were reported, has been silently circulated in West Africa for the last two decades when blood samples collected between 1992 and 2016 were tested for the ZIKV IgM antibodies.

Micronesia, 2007

In April 2007, the first outbreak outside of Africa and Asia occurred on the island of Yap in the Federated States of Micronesia, characterized by rash, conjunctivitis, and arthralgia, which was initially thought to be dengue, chikungunya, or Ross River disease. Serum samples from patients in the acute phase of illness contained RNA of Zika. There were 49 confirmed cases, 59 unconfirmed cases, no hospitalizations, and no deaths.

2013–2014

After October 2013 Oceania's first outbreak showed an estimated 11% population infected for French Polynesia that also presented with Guillain–Barre syndrome (GBS). The spread of ZIKV continued to New Caledonia, Easter Island, and the Cook Islands and where 1385 cases were confirmed by January 2014. During the same year, Easter Island acknowledged 51 cases. Australia began seeing cases in 2012. Research showed it was brought by travelers returning from Indonesia and other infected countries. New Zealand also experienced infections rate increases through returning foreign travelers. Oceania countries experiencing Zika today are New Caledonia, Vanuatu, Solomon Islands, Marshall Islands, American Samoa, Samoa, and Tonga.

Between 2013 and 2014, further epidemics occurred in French Polynesia, Easter Island, the Cook Islands, and New Caledonia.

Americas, 2015–present

Image of a baby with microcephaly (left) compared to a normal baby (right). This is one of the potential effects of Zika virus. Signs of microcephaly may develop a few months after birth.

There was an epidemic in 2015 and 2016 in the Americas. The outbreak began in April 2015 in Brazil, and spread to other countries in South America, Central America, North America, and the Caribbean. In January 2016, the WHO said the virus was likely to spread throughout most of the Americas by the end of the year; and in February 2016, the WHO declared the cluster of microcephaly and Guillain–Barré syndrome cases reported in Brazil – strongly suspected to be associated with the Zika outbreak – a Public Health Emergency of International Concern. It was estimated that 1.5 million people were infected by Zika in Brazil, with over 3,500 cases of microcephaly reported between October 2015 and January 2016.

A number of countries issued travel warnings, and the outbreak was expected to significantly impact the tourism industry. Several countries have taken the unusual step of advising their citizens to delay pregnancy until more is known about the virus and its impact on fetal development. With the 2016 Summer Olympics hosted in Rio de Janeiro, health officials worldwide voiced concerns over a potential crisis, both in Brazil and when international athletes and tourists returned home and possibly would spread the virus. Some researchers speculated that only one or two tourists might be infected during the three-week period, or approximately 3.2 infections per 100,000 tourists. In November 2016, the World Health Organization declared that Zika virus was no longer a global emergency while noting that the virus still represents "a highly significant and a long-term problem".

As of August 2017 the number of new Zika virus cases in the Americas had fallen dramatically.

India

On May 15, 2017, three cases of Zika virus infection in India were reported in the state of Gujarat. By late 2018, there had been at least 159 cases in Rajasthan and 127 in Madhya Pradesh.

In July 2021, the first case of Zika virus infection in the Indian state of Kerala was reported. After the first confirmed case, 19 other people who had previously presented symptoms were tested, and 13 of those had positive results, showing that Zika had been circulating in Kerala since at least May 2021. By August 6th 2021, there had been 65 reported cases in Kerala.

In October 22, 2021, an officer in the Indian Air Force in Kanpur tested positive for Zika virus, making it the first reported case in the Indian state of Uttar Pradesh.

Other cases

On 22 March 2016, Reuters reported that Zika was isolated from a 2014 blood sample of an elderly man in Chittagong in Bangladesh as part of a retrospective study. Zika is also occurring in Tanzania as of 2016.

Between August and November 2016, 455 cases of Zika virus infection were confirmed in Singapore.

In 2017, Angola reported two cases of Zika fever.

  1. Goldsmith C (18 March 2005). "TEM image of the Zika virus". Centers for Disease Control and Prevention. Retrieved4 March 2016.
  2. Sirohi D, Chen Z, Sun L, Klose T, Pierson TC, Rossmann MG, Kuhn RJ (April 2016). "The 3.8 Å resolution cryo-EM structure of Zika virus". Science. 352 (6284): 467–470. Bibcode:2016Sci...352..467S. doi:10.1126/science.aaf5316. PMC4845755. PMID 27033547.
  3. "How to pronounce Zika". HowToPronounce.com.
  4. "Zika virus". Emerging Infectious Diseases. 20 (6): 1090. June 2014. doi:10.3201/eid2006.ET2006. PMC4036762. PMID 24983096.
  5. Malone RW, Homan J, Callahan MV, Glasspool-Malone J, Damodaran L, Schneider A, et al. (March 2016). "Zika Virus: Medical Countermeasure Development Challenges". PLOS Neglected Tropical Diseases. 10 (3): e0004530. doi:10.1371/journal.pntd.0004530. PMC4774925. PMID 26934531.
  6. Sikka V, Chattu VK, Popli RK, Galwankar SC, Kelkar D, Sawicki SG, Stawicki SP, Papadimos TJ (11 February 2016). "The Emergence of Zika Virus as a Global Health Security Threat: A Review and a Consensus Statement of the INDUSEM Joint working Group (JWG)". Journal of Global Infectious Diseases. 8 (1): 3–15. doi:10.4103/0974-777X.176140. PMC4785754. PMID 27013839.
  7. Mehrjardi MZ (1 January 2017). "Is Zika Virus an Emerging TORCH Agent? An Invited Commentary". Virology. 8: 1178122X17708993. doi:10.1177/1178122X17708993. PMC5439991. PMID 28579764.
  8. "Symptoms, Diagnosis, & Treatment". Zika virus. Atlanta: Centers for Disease Control and Prevention. 3 March 2016. Retrieved4 March 2016.
  9. Abbink, P; Stephenson, KE; Barouch, DH (19 June 2018). "Zika virus vaccines". Nature Reviews. Microbiology. 16 (10): 594–600. doi:10.1038/s41579-018-0039-7. PMC6162149. PMID 29921914.
  10. Fernandez, E; Diamond, MS (19 April 2017). "Vaccination strategies against Zika virus". Current Opinion in Virology. 23: 59–67. doi:10.1016/j.coviro.2017.03.006. PMC5576498. PMID 28432975.
  11. "Zika Virus Vaccines | NIH: National Institute of Allergy and Infectious Diseases". www.niaid.nih.gov.
  12. Rasmussen SA, Jamieson DJ, Honein MA, Petersen LR (May 2016). "Zika virus and birth defects – Reviewing the Evidence for Causality". The New England Journal of Medicine. 374 (20): 1981–1987. doi:10.1056/NEJMsr1604338. PMID 27074377. S2CID 20675635.
  13. "CDC concludes Zika causes microcephaly and other birth defects". CDC. 13 April 2016. Retrieved14 April 2016.
  14. "Zika virus microcephaly and Guillain–Barré syndrome situation report"(PDF). World Health Organization. 7 April 2016. Retrieved8 April 2016.
  15. "Zika Virus in the Caribbean". Travelers' Health: Travel Notices. Centers for Disease Control and Prevention. 15 January 2016.
  16. Petersen EE, Staples JE, Meaney-Delman D, Fischer M, Ellington SR, Callaghan WM, Jamieson DJ (January 2016). "Interim Guidelines for Pregnant Women During a Zika Virus Outbreak – United States, 2016". MMWR. Morbidity and Mortality Weekly Report. 65 (2): 30–33. doi:10.15585/mmwr.mm6502e1. PMID 26796813.
  17. "Zika virus: Advice for those planning to travel to outbreak areas". ITV Report. ITV News. 22 January 2016. Retrieved24 January 2016.
  18. "Pregnant Irish women warned over Zika virus in central and South America". RTÉ News. 22 January 2016. Retrieved23 January 2016.
  19. "Zika: Olympics plans announced by Rio authorities". BBC News. British Broadcasting Corporation. 24 January 2016. Retrieved24 January 2016. The Rio de Janeiro authorities have announced plans to prevent the spread of the Zika virus during the Olympic Games later this year. ... The US, Canada and EU health agencies have issued warnings saying pregnant women should avoid traveling to Brazil and other countries in the Americas which have registered cases of Zika.
  20. "Zika virus triggers pregnancy delay calls". BBC News. 23 January 2016. Retrieved23 January 2016.
  21. Knipe DM, Howley PM (2007). Fields Virology (5th ed.). Lippincott Williams & Wilkins. pp. 1156, 1199. ISBN 978-0-7817-6060-7.
  22. Faye O, Freire CC, Iamarino A, Faye O, de Oliveira JV, Diallo M, et al. (9 January 2014). "Molecular evolution of Zika virus during its emergence in the 20(th) century". PLOS Neglected Tropical Diseases. 8 (1): e2636. doi:10.1371/journal.pntd.0002636. PMC3888466. PMID 24421913.
  23. Cao-Lormeau VM, Roche C, Teissier A, Robin E, Berry AL, Mallet HP, et al. (June 2014). "Zika virus, French polynesia, South pacific, 2013". Emerging Infectious Diseases. 20 (6): 1085–1086. doi:10.3201/eid2006.140138. PMC4036769. PMID 24856001.
  24. Hayes EB (September 2009). "Zika virus outside Africa". Emerging Infectious Diseases. 15 (9): 1347–1350. doi:10.3201/eid1509.090442. PMC2819875. PMID 19788800.
  25. Kuno G, Chang GJ (1 January 2007). "Full-length sequencing and genomic characterization of Bagaza, Kedougou, and Zika viruses". Archives of Virology. 152 (4): 687–696. doi:10.1007/s00705-006-0903-z. PMID 17195954.
  26. Goodsell DS (2016). "Zika Virus". RCSB Protein Data Bank. doi:10.2210/rcsb_pdb/mom_2016_5.
  27. Cox BD, Stanton RA, Schinazi RF (August 2015). "Predicting Zika virus structural biology: Challenges and opportunities for intervention". Antiviral Chemistry & Chemotherapy. 24 (3–4): 118–126. doi:10.1177/2040206616653873. PMC5890524. PMID 27296393.
  28. Dai L, Song J, Lu X, Deng YQ, Musyoki AM, Cheng H, et al. (May 2016). "Structures of the Zika Virus Envelope Protein and Its Complex with a Flavivirus Broadly Protective Antibody". Cell Host & Microbe. 19 (5): 696–704. doi:10.1016/j.chom.2016.04.013. PMID 27158114.
  29. "ViralZone: Zika virus (strain Mr 766)". viralzone.expasy.org. SIB Swiss Institute of Bioinformatics. Retrieved24 August 2016.
  30. Pierson TC, Diamond MS (April 2012). "Degrees of maturity: the complex structure and biology of flaviviruses". Current Opinion in Virology. 2 (2): 168–175. doi:10.1016/j.coviro.2012.02.011. PMC3715965. PMID 22445964.
  31. Akiyama B, Laurence H, Massey A, Costantino D, Xie X, Yang Y, et al. (December 2016). "Zika virus produces noncoding RNAs using a multi-pseudoknot structure that confounds a cellular exonuclease". Science. 354 (6316): 1148–1152. doi:10.1126/science.aah3963. PMID 27934765.
  32. Monel B, Compton AA, Bruel T, Amraoui S, Burlaud-Gaillard J, Roy N, et al. (June 2017). "Zika virus induces massive cytoplasmic vacuolization and paraptosis-like death in infected cells". The EMBO Journal. 36 (12): 1653–1668. doi:10.15252/embj.201695597. PMC5470047. PMID 28473450.
  33. Enfissi A, Codrington J, Roosblad J, Kazanji M, Rousset D (January 2016). "Zika virus genome from the Americas". Lancet. 387 (10015): 227–228. doi:10.1016/S0140-6736(16)00003-9. PMID 26775124.
  34. Zanluca C, Melo VC, Mosimann AL, Santos GI, Santos CN, Luz K (June 2015). "First report of autochthonous transmission of Zika virus in Brazil". Memórias do Instituto Oswaldo Cruz. 110 (4): 569–572. doi:10.1590/0074-02760150192. PMC4501423. PMID 26061233.
  35. Lanciotti RS, Lambert AJ, Holodniy M, Saavedra S, Signor L (May 2016). "Phylogeny of Zika Virus in Western Hemisphere, 2015". Emerging Infectious Diseases. 22 (5): 933–935. doi:10.3201/eid2205.160065. PMC4861537. PMID 27088323.
  36. Ramaiah A, Dai L, Contreras D, Sinha S, Sun R, Arumugaswami V (July 2017). "Comparative analysis of protein evolution in the genome of pre-epidemic and epidemic Zika virus". Infection, Genetics and Evolution. 51: 74–85. doi:10.1016/j.meegid.2017.03.012. PMID 28315476.
  37. Fauci AS, Morens DM (February 2016). "Zika Virus in the Americas--Yet Another Arbovirus Threat". The New England Journal of Medicine. 374 (7): 601–604. doi:10.1056/NEJMp1600297. PMID 26761185. S2CID 4377569.
  38. Gubler DJ (December 2011). "Dengue, Urbanization and Globalization: The Unholy Trinity of the 21(st) Century". Tropical Medicine and Health. 39 (4 Suppl): 3–11. doi:10.2149/tmh.2011-S05. PMC3317603. PMID 22500131.
  39. "Zika virus found in common house mosquitoes in Brazil". CNN. 22 July 2016. Retrieved23 July 2016.
  40. Oster AM, Russell K, Stryker JE, Friedman A, Kachur RE, Petersen EE, et al. (April 2016). "Update: Interim Guidance for Prevention of Sexual Transmission of Zika Virus--United States, 2016". MMWR. Morbidity and Mortality Weekly Report. 65 (12): 323–325. doi:10.15585/mmwr.mm6512e3. PMID 27032078.
  41. Vasquez AM, Sapiano MR, Basavaraju SV, Kuehnert MJ, Rivera-Garcia B (April 2016). "Survey of Blood Collection Centers and Implementation of Guidance for Prevention of Transfusion-Transmitted Zika Virus Infection--Puerto Rico, 2016". MMWR. Morbidity and Mortality Weekly Report. 65 (14): 375–378. doi:10.15585/mmwr.mm6514e1. PMID 27078190.
  42. "Assessing the global threat from Zika virus". Science Magazine. 12 August 2016. Retrieved15 August 2016 – via www.sciencemagazinedigital.org.
  43. Moloney A (22 January 2016). "FACTBOX – Zika virus spreads rapidly through Latin America, Caribbean". Thomson Reuters Foundation News. Retrieved26 January 2016.
  44. Mitchell C (18 January 2016). "As the Zika virus spreads, PAHO advises countries to monitor and report birth anomalies and other suspected complications of the virus". Media Center. Pan American Health Organization. Retrieved25 January 2016.
  45. Mitchell C (2 February 2016). "PAHO Statement on Zika Virus Transmission and Prevention". PAHO.org. Pan American Health Organization.
  46. "5 things you need to know about Zika". CNN. 24 February 2016.
  47. "Zika Virus". All Countries & Territories with Active Zika Virus Transmission. Centers for Disease Control and Prevention. Archived from the original on 21 September 2017. Retrieved15 August 2016.
  48. Abushouk AI, Negida A, Ahmed H (November 2016). "An updated review of Zika virus". Journal of Clinical Virology. 84: 53–58. doi:10.1016/j.jcv.2016.09.012. PMID 27721110.
  49. Ayres CF (March 2016). "Identification of Zika virus vectors and implications for control". The Lancet. Infectious Diseases. 16 (3): 278–279. doi:10.1016/S1473-3099(16)00073-6. PMID 26852727.
  50. Division of Vector-Borne Diseases, Dengue Branch. "Dengue and the Aedes aegypti mosquito"(PDF). Centers for Disease Control and Prevention. Retrieved2 February 2012.
  51. Wishart S (July–August 2018). "Shining a light on Zika". New Zealand Geographic (152): 25.
  52. Grard G, Caron M, Mombo IM, Nkoghe D, Mboui Ondo S, Jiolle D, Fontenille D, Paupy C, Leroy EM (February 2014). "Zika virus in Gabon (Central Africa) – 2007: a new threat from Aedes albopictus?". PLOS Neglected Tropical Diseases. 8 (2): e2681. doi:10.1371/journal.pntd.0002681. PMC3916288. PMID 24516683.
  53. Zammarchi L, Stella G, Mantella A, Bartolozzi D, Tappe D, Günther S, et al. (February 2015). "Zika virus infections imported to Italy: clinical, immunological and virological findings, and public health implications". Journal of Clinical Virology. 63: 32–35. doi:10.1016/j.jcv.2014.12.005. PMID 25600600.
  54. Kraemer MU, Sinka ME, Duda KA, Mylne AQ, Shearer FM, Barker CM, et al. (June 2015). "The global distribution of the arbovirus vectors Aedes aegypti and Ae. albopictus". eLife. 4: e08347. doi:10.7554/eLife.08347. PMC4493616. PMID 26126267.
  55. "Aedes aegypti". Health Topics: Vectors: Mosquitos. European Centre for Disease Protection and Control. Retrieved25 January 2016.
  56. Craig S, Collins B (26 January 2016). "Mosquitoes capable of carrying Zika virus found in Washington, D.C." Notre Dame News. University of Notre Dame.
  57. "Zika outbreak: What you need to know". BBC News. Retrieved31 July 2016.
  58. "How to Avoid Mosquito Bites in Florida". 10 June 2013. Retrieved31 July 2016.
  59. "Zika Virus: Symptoms, Transmission & Solution | SA News Channel". S A NEWS. 9 July 2021. Retrieved10 July 2021.
  60. Carlson CJ, Dougherty ER, Getz W (August 2016). "An Ecological Assessment of the Pandemic Threat of Zika Virus". PLOS Neglected Tropical Diseases. 10 (8): e0004968. doi:10.1371/journal.pntd.0004968. PMC5001720. PMID 27564232.
  61. Slonchak A, Hugo L, Freney M, Hall-Mendelin S, Amarilla A, Torres F, Setoh Y, Peng N, Sng J, Hall R, van den Hurk A, Devine G, Khromykh (May 2020). "Zika virus noncoding RNA suppresses apoptosis and is required for virus transmission by mosquitoes". Nature Communications. 11 (1): 2205. Bibcode:2020NatCo..11.2205S. doi:10.1038/s41467-020-16086-y. PMC7200751. PMID 32371874.
  62. Oussayef NL, Pillai SK, Honein MA, Ben Beard C, Bell B, Boyle CA, et al. (January 2017). "Zika Virus -10 Public Health Achievements in 2016 and Future Priorities". MMWR. Morbidity and Mortality Weekly Report. 65 (52): 1482–1488. doi:10.15585/mmwr.mm6552e1. PMID 28056005.
  63. "WHO chief going to the Olympics, says Zika risk low". Reuters. 29 July 2016. According to Margaret Chan, the director of the WHO, 'Of course, we also have learnt from the latest evidence it's not just infected men who can pass the disease to their sex partners. There was a case of a lady passing the disease to a man, so it can go both directions.'
  64. Le Tortorec A, Matusali G, Mahé D, Aubry F, Mazaud-Guittot S, Houzet L, Dejucq-Rainsford N (July 2020). "From Ancient to Emerging Infections: The Odyssey of Viruses in the Male Genital Tract"(PDF). Physiological Reviews. 100 (3): 1349–1414. doi:10.1152/physrev.00021.2019. PMID 32031468. S2CID 211045539.
  65. Matusali G, Houzet L, Satie AP, Mahé D, Aubry F, Couderc T, et al. (October 2018). "Zika virus infects human testicular tissue and germ cells". The Journal of Clinical Investigation. 128 (10): 4697–4710. doi:10.1172/JCI121735. PMC6159993. PMID 30063220.
  66. Joguet G, Mansuy JM, Matusali G, Hamdi S, Walschaerts M, Pavili L, et al. (November 2017). "Effect of acute Zika virus infection on sperm and virus clearance in body fluids: a prospective observational study". The Lancet. Infectious Diseases. 17 (11): 1200–1208. doi:10.1016/S1473-3099(17)30444-9. PMID 28838639.
  67. Petersen EE, Meaney-Delman D, Neblett-Fanfair R, Havers F, Oduyebo T, Hills SL, et al. (October 2016). "Update: Interim Guidance for Preconception Counseling and Prevention of Sexual Transmission of Zika Virus for Persons with Possible Zika Virus Exposure - United States, September 2016". MMWR. Morbidity and Mortality Weekly Report. 65 (39): 1077–1081. doi:10.15585/mmwr.mm6539e1. PMID 27711033.
  68. "CDC Zika: Transmission". Centers for Disease Control and Prevention. 15 April 2016. Archived from the original on 20 September 2017. Retrieved17 April 2016.
  69. Paploski IA, Prates AP, Cardoso CW, Kikuti M, Silva MM, Waller LA, et al. (August 2016). "Time Lags between Exanthematous Illness Attributed to Zika Virus, Guillain-Barré Syndrome, and Microcephaly, Salvador, Brazil". Emerging Infectious Diseases. 22 (8): 1438–1444. doi:10.3201/eid2208.160496. PMC4982160. PMID 27144515.
  70. Aguilar Ticona, Juan P.; Nery, Nivison; Ladines-Lim, Joseph B.; Gambrah, Claudia; Sacramento, Gielson; de Paula Freitas, Bruno; Bouzon, Joseane; Oliveira-Filho, Jamary; Borja, Ana; Adhikarla, Haritha; Montoya, Magelda (5 February 2021). Ramos, Alberto Novaes (ed.). "Developmental outcomes in children exposed to Zika virus in utero from a Brazilian urban slum cohort study". PLOS Neglected Tropical Diseases. 15 (2): e0009162. doi:10.1371/journal.pntd.0009162. ISSN 1935-2735. PMC7891708. PMID 33544730.
  71. Rubin EJ, Greene MF, Baden LR (March 2016). "Zika Virus and Microcephaly". The New England Journal of Medicine. 374 (10): 984–985. doi:10.1056/NEJMe1601862. PMID 26862812. S2CID 205079825.
  72. Stanelle-Bertram S, Walendy-Gnirß K, Speiseder T, Thiele S, Asante IA, Dreier C, et al. (October 2018). "Male offspring born to mildly ZIKV-infected mice are at risk of developing neurocognitive disorders in adulthood". Nature Microbiology. 3 (10): 1161–1174. doi:10.1038/s41564-018-0236-1. hdl:10138/306618. PMID 30202017. S2CID 52181681.
  73. Kikuti M, Cardoso CW, Prates AP, Paploski IA, Kitron U, Reis MG, et al. (November 2018). "Congenital brain abnormalities during a Zika virus epidemic in Salvador, Brazil, April 2015 to July 2016". Euro Surveillance. 23 (45): 1–10. doi:10.2807/1560-7917.ES.2018.23.45.1700757. PMC6234531. PMID 30424827.
  74. Rathore AP, Saron WA, Lim T, Jahan N, St John AL (February 2019). "Maternal immunity and antibodies to dengue virus promote infection and Zika virus-induced microcephaly in fetuses". Science Advances. 5 (2): eaav3208. Bibcode:2019SciA....5.3208R. doi:10.1126/sciadv.aav3208. PMC6392794. PMID 30820456.
  75. Brown JA, Singh G, Acklin JA, Lee S, Duehr JE, Chokola AN, et al. (January 2019). "Dengue Virus Immunity Increases Zika Virus-Induced Damage during Pregnancy". Immunity. 50 (3): 751–762.e5. doi:10.1016/j.immuni.2019.01.005. PMC6947917. PMID 30737148.
  76. "Recommendations for Donor Screening, Deferral, and Product Management to Reduce the Risk of Transfusion-Transmission of Zika Virus"(PDF). Food and Drug Administration. February 2016.
  77. "Zika virus infection outbreak, Brazil and the Pacific region"(PDF). Rapid Risk Assessments. Stockholm: European Centre for Disease Prevention and Control. 25 May 2015. pp. 4–5. Archived from the original(PDF) on 13 October 2015. Retrieved12 February 2016.
  78. Musso D, Nhan T, Robin E, Roche C, Bierlaire D, Zisou K, et al. (April 2014). "Potential for Zika virus transmission through blood transfusion demonstrated during an outbreak in French Polynesia, November 2013 to February 2014". Euro Surveillance. 19 (14): 20761. doi:10.2807/1560-7917.es2014.19.14.20761. PMID 24739982.
  79. Chan JF, Choi GK, Yip CC, Cheng VC, Yuen KY (May 2016). "Zika fever and congenital Zika syndrome: An unexpected emerging arboviral disease". The Journal of Infection. 72 (5): 507–524. doi:10.1016/j.jinf.2016.02.011. hdl:10722/231183. PMC7112603. PMID 26940504.
  80. Buckley A, Gould EA (August 1988). "Detection of virus-specific antigen in the nuclei or nucleoli of cells infected with Zika or Langat virus". The Journal of General Virology. 69 (8): 1913–1920. doi:10.1099/0022-1317-69-8-1913. PMID 2841406.
  81. Molly Chiu (14 November 2019). "How maternal Zika virus infection results in newborn microcephaly". ScienMag. Retrieved17 November 2019.
  82. Harsh S, Fu Y, Kenney E, Han Z, Eleftherianos I (April 2020). "Drosophila through regulation of JAK/STAT signaling". Disease Models & Mechanisms. 13 (4): dmm040816. doi:10.1242/dmm.040816. PMC7197722. PMID 32152180.
  83. "Zika virus". World Health Organization. January 2016. Retrieved3 February 2016.
  84. "Factsheet for health professionals". Health topics: Zika virus infection. European Centre for Disease Prevention and Control. Retrieved22 December 2015.
  85. Chen LH, Hamer DH (May 2016). "Zika Virus: Rapid Spread in the Western Hemisphere". Annals of Internal Medicine. 164 (9): 613–615. doi:10.7326/M16-0150. PMID 26832396.
  86. Musso D, Nilles EJ, Cao-Lormeau VM (October 2014). "Rapid spread of emerging Zika virus in the Pacific area". Clinical Microbiology and Infection. 20 (10): O595-6. doi:10.1111/1469-0691.12707. PMID 24909208.
  87. Dhiman G, Abraham R, Griffin DE (July 2019). "Human Schwann cells are susceptible to infection with Zika and yellow fever viruses, but not dengue virus". Scientific Reports. 9 (1): 9951. Bibcode:2019NatSR...9.9951D. doi:10.1038/s41598-019-46389-0. PMC6616448. PMID 31289325.
  88. "Zika diagnostic test granted market authorization by FDA". Washington University School of Medicine in St. Louis. 3 September 2019. Retrieved14 February 2020.
  89. Oster AM, Russell K, Stryker JE, Friedman A, Kachur RE, Petersen EE, et al. (April 2016). "Update: Interim Guidance for Prevention of Sexual Transmission of Zika Virus--United States, 2016". MMWR. Morbidity and Mortality Weekly Report. 65 (12): 323–325. doi:10.15585/mmwr.mm6512e3. PMID 27032078.
  90. "Brazil warns against pregnancy due to spreading virus". CNN. 24 December 2015. Retrieved24 December 2015.
  91. "WHO and experts prioritize vaccines, diagnostics and innovative vector control tools for Zika R&D". World Health Organization. 9 March 2016. Retrieved13 March 2016.
  92. Cook J (27 January 2016). "Zika virus: US scientists say vaccine '10 years away'". BBC News. Retrieved28 January 2016.
  93. Sagonowsky E (21 June 2016). "Inovio set for first Zika vaccine human trial". fiercepharma.com. Retrieved1 July 2016.
  94. "Phase 2 Zika vaccine trial begins in U.S., Central and South America". National Institutes of Health (NIH). 31 March 2017.
  95. Fernandez E, Diamond MS (April 2017). "Vaccination strategies against Zika virus". Current Opinion in Virology. 23: 59–67. doi:10.1016/j.coviro.2017.03.006. PMC5576498. PMID 28432975.
  96. "Geographic Distribution". Zika Virus. Centers for Disease Control and Prevention. 5 November 2014. Retrieved18 January 2016.
  97. Gatherer D, Kohl A (February 2016). "Zika virus: a previously slow pandemic spreads rapidly through the Americas"(PDF). The Journal of General Virology. 97 (2): 269–273. doi:10.1099/jgv.0.000381. PMID 26684466.
  98. "Zika virus in the United States". Centers for Disease Control and Prevention. Archived from the original on 20 February 2016. Retrieved20 February 2016.
  99. Cohen J (8 February 2016). "Zika's long, strange trip into the limelight". Science. American Association for the Advancement of Science. Retrieved10 February 2016.
  100. Haddow AD, Schuh AJ, Yasuda CY, Kasper MR, Heang V, Huy R, et al. (2012). "Genetic characterization of Zika virus strains: geographic expansion of the Asian lineage". PLOS Neglected Tropical Diseases. 6 (2): e1477. doi:10.1371/journal.pntd.0001477. PMC3289602. PMID 22389730.
  101. Wikan N, Smith DR (July 2016). "Zika virus: history of a newly emerging arbovirus". The Lancet. Infectious Diseases. 16 (7): e119–e126. doi:10.1016/s1473-3099(16)30010-x. PMID 27282424.
  102. Dick GW (September 1952). "Zika virus. II. Pathogenicity and physical properties". Transactions of the Royal Society of Tropical Medicine and Hygiene. 46 (5): 521–534. doi:10.1016/0035-9203(52)90043-6. PMID 12995441.
  103. Macnamara FN (March 1954). "Zika virus: A report on three cases of human infection during an epidemic of jaundice in Nigeria". Transactions of the Royal Society of Tropical Medicine and Hygiene. 48 (2): 139–145. doi:10.1016/0035-9203(54)90006-1. PMID 13157159.
  104. Wikan N, Smith DR (January 2017). "First published report of Zika virus infection in people: Simpson, not MacNamara". The Lancet. Infectious Diseases. 17 (1): 15–17. doi:10.1016/S1473-3099(16)30525-4. PMID 27998553.
  105. Bearcroft WG (September 1956). "Zika virus infection experimentally induced in a human volunteer". Transactions of the Royal Society of Tropical Medicine and Hygiene. 50 (5): 442–448. doi:10.1016/0035-9203(56)90091-8. PMID 13380987.
  106. Simpson DI (July 1964). "Zika virus infection in man". Transactions of the Royal Society of Tropical Medicine and Hygiene. 58 (4): 335–338. doi:10.1016/0035-9203(64)90201-9. PMID 14175744.
  107. Ramzy, Austin (10 February 2016). "Experts Study Zika's Path From First Outbreak in Pacific". The New York Times. Hong Kong. Retrieved12 February 2016.
  108. Henry, Martha (24 May 2017). "Zika virus found to be circulating in Africa for decades". Harvard T.H.Chan School of Public Health. Retrieved5 June 2017.
  109. Altman LK (3 July 2007). "Little-Known Virus Challenges a Far-Flung Health System". The New York Times.
  110. Duffy MR, Chen TH, Hancock WT, Powers AM, Kool JL, Lanciotti RS, et al. (June 2009). "Zika virus outbreak on Yap Island, Federated States of Micronesia". The New England Journal of Medicine. 360 (24): 2536–2543. doi:10.1056/NEJMoa0805715. PMID 19516034.
  111. Saiz JC, Vázquez-Calvo Á, Blázquez AB, Merino-Ramos T, Escribano-Romero E, Martín-Acebes MA (19 April 2016). "Zika Virus: the Latest Newcomer". Frontiers in Microbiology. 7: 496. doi:10.3389/fmicb.2016.00496. PMC4835484. PMID 27148186.
  112. "WHO sees Zika outbreak spreading through the Americas". Reuters. 25 January 2016. Retrieved25 January 2016.
  113. "WHO Director-General summarizes the outcome of the Emergency Committee regarding clusters of microcephaly and Guillain–Barré syndrome". World Health Organization. 1 February 2016. Retrieved2 February 2016.
  114. Roberts M (1 February 2016). "Zika-linked condition: WHO declares global emergency". BBC News. Retrieved1 February 2016.
  115. Pearson, Michael (2 February 2016). "Zika virus sparks 'public health emergency'". CNN. Retrieved2 February 2016.
  116. Boadle A, Brown T, Orr B (18 February 2016). "U.S., Brazil researchers join forces to battle Zika virus". Reuters. Brasilia. Retrieved4 March 2016.
  117. "Microcephaly in Brazil potentially linked to the Zika virus epidemic, ECDC assesses the risk". News and Media. European Centre for Disease Prevention and Control. 25 November 2015. Retrieved18 January 2016.
  118. Kiernan P, Jelmayer R (3 February 2016). "Zika Fears Imperil Brazil's Tourism Push". The Wall Street Journal. Retrieved27 February 2016.
  119. Belluz J (26 May 2016). "Rio Olympics 2016: why athletes and fans aren't likely to catch Zika". Vox. Retrieved1 June 2016.
  120. "World Health Organization declares end of Zika emergency". The Irish Times. Retrieved18 November 2016.
  121. Cohen J (16 August 2017). "Zika has all but disappeared in the Americas. Why?". Science. doi:10.1126/science.aao6984.
  122. "2017 - India". World Health Organization. 26 May 2017. Retrieved26 October 2021.
  123. Bhardwaj, Sumit; Gokhale, Mangesh D; Mourya, Devendra T (November 2017). "Zika virus: Current concerns in India". Indian Journal of Medical Research. 146 (5): 572–575. doi:10.4103/ijmr.IJMR_1160_17 (inactive 4 November 2021). PMC5861468. PMID 29512599.CS1 maint: DOI inactive as of November 2021 (link)
  124. Rolph, Michael S; Mahalingam, Suresh (1 May 2019). "Zika's passage to India". The Lancet. Infectious Diseases. 19 (5): 469–470. doi:10.1016/S1473-3099(19)30169-0. PMID 31034391. S2CID 140302216.
  125. "Zika Virus Disease – India". World Health Organization. 14 October 2021. Retrieved26 October 2021.
  126. "65 Zika virus cases reported in Kerala as on August 2, 2021: Health minister Mansukh Mandaviya". The Economic Times. 6 August 2021. Retrieved26 October 2021.
  127. Singh, Ranjal (24 October 2021). "Zika virus case detected in Kanpur, first in Uttar Pradesh". India Today. Retrieved26 October 2021.
  128. "Bangladesh Confirms First Case of Zika Virus". Newsweek. 22 March 2016. Retrieved22 March 2016.
  129. "Blood samples show presence of Zika virus in Tanzania". Anadolu Agency. Retrieved19 December 2016.
  130. Ho ZJ, Hapuarachchi HC, Barkham T, Chow A, Ng LC, Lee JM, et al. (Singapore Zika Study Group) (August 2017). "Outbreak of Zika virus infection in Singapore: An epidemiological, entomological, virological, and clinical analysis". The Lancet. Infectious Diseases. 17 (8): 813–821. doi:10.1016/S1473-3099(17)30249-9. PMID 28527892.
  131. "Zika Virus in Singapore". CDC. Retrieved3 September 2016.
  132. "Angola reports first two cases of Zika virus". Reuters. 11 January 2017. Retrieved18 January 2017.

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Zika virus
Zika virus Language Watch Edit This article is about the virus For the disease see Zika fever For the recent outbreak see 2015 2016 Zika virus epidemic Zika virus ZIKV pronounced ˈ z iː k e or ˈ z ɪ k e 3 4 is a member of the virus family Flaviviridae 5 It is spread by daytime active Aedes mosquitoes such as A aegypti and A albopictus 5 Its name comes from the Ziika Forest of Uganda where the virus was first isolated in 1947 6 Zika virus shares a genus with the dengue yellow fever Japanese encephalitis and West Nile viruses 6 Since the 1950s it has been known to occur within a narrow equatorial belt from Africa to Asia From 2007 to 2016 update the virus spread eastward across the Pacific Ocean to the Americas leading to the 2015 2016 Zika virus epidemic 7 Zika virusElectron micrograph of Zika virus Virus particles digitally colored purple are 40 nm in diameter with an outer envelope and a dense inner core 1 Zika virus capsid model colored by chains PDB entry 5ire 2 Virus classification unranked VirusRealm RiboviriaKingdom OrthornaviraePhylum KitrinoviricotaClass FlasuviricetesOrder AmarilloviralesFamily FlaviviridaeGenus FlavivirusSpecies Zika virus The infection known as Zika fever or Zika virus disease often causes no or only mild symptoms similar to a very mild form of dengue fever 5 While there is no specific treatment paracetamol acetaminophen and rest may help with the symptoms 8 As of April 2019 no vaccines have been approved for clinical use however a number of vaccines are currently in clinical trials 9 10 11 Zika can spread from a pregnant woman to her baby This can result in microcephaly severe brain malformations and other birth defects 12 13 Zika infections in adults may result rarely in Guillain Barre syndrome 14 In January 2016 the United States Centers for Disease Control and Prevention CDC issued travel guidance on affected countries including the use of enhanced precautions and guidelines for pregnant women including considering postponing travel 15 16 Other governments or health agencies also issued similar travel warnings 17 18 19 while Colombia the Dominican Republic Puerto Rico Ecuador El Salvador and Jamaica advised women to postpone getting pregnant until more is known about the risks 18 20 Contents 1 Virology 2 Transmission 2 1 Mosquito 2 2 Sexual 2 3 Pregnancy 2 4 Blood transfusion 3 Pathogenesis 4 Zika fever 4 1 Vaccine development 5 History 5 1 Virus isolation in monkeys and mosquitoes 1947 5 2 First evidence of human infection 1952 5 3 Spread in equatorial Africa and to Asia 1951 2016 5 4 Micronesia 2007 5 5 2013 2014 5 6 Americas 2015 present 5 7 India 5 8 Other cases 6 References 7 External linksVirology EditZika virus belongs to the family Flaviviridae and the genus Flavivirus thus is related to the dengue yellow fever Japanese encephalitis and West Nile viruses Like other flaviviruses Zika virus is enveloped and icosahedral and has a nonsegmented single stranded 10 kilobase positive sense RNA genome It is most closely related to the Spondweni virus and is one of the two known viruses in the Spondweni virus clade 21 22 23 24 25 Cross section of Zika virus showing the viral envelope composed of envelope proteins red and membrane proteins purple embedded in the lipid membrane white The capsid proteins orange are shown interacting with the RNA genome yellow at the center of the virus 26 A positive sense RNA genome can be directly translated into viral proteins As in other flaviviruses such as the similarly sized West Nile virus the RNA genome encodes seven nonstructural proteins and three structural proteins in the form of a single polyprotein Q32ZE1 27 One of the structural proteins encapsulates the virus This protein is the flavivirus envelope glycoprotein that binds to the endosomal membrane of the host cell to initiate endocytosis 28 The RNA genome forms a nucleocapsid along with copies of the 12 kDa capsid protein The nucleocapsid in turn is enveloped within a host derived membrane modified with two viral glycoproteins Viral genome replication depends on the making of double stranded RNA from the single stranded positive sense RNA ssRNA genome followed by transcription and replication to provide viral mRNAs and new ssRNA genomes 29 30 The 3 untranslated region 3 UTR of Zika contains highly structured RNAs that stall the processivity of the XRN1 exoribonuclease leading to production of the subgenomic flavivirus RNA sfRNA 31 A longitudinal study shows that 6 hours after cells are infected with Zika virus the vacuoles and mitochondria in the cells begin to swell This swelling becomes so severe it results in cell death also known as paraptosis This form of programmed cell death requires gene expression IFITM3 is a trans membrane protein in a cell that is able to protect it from viral infection by blocking virus attachment Cells are most susceptible to Zika infection when levels of IFITM3 are low Once the cell has been infected the virus restructures the endoplasmic reticulum forming the large vacuoles resulting in cell death 32 There are two Zika lineages the African lineage and the Asian lineage 33 Phylogenetic studies indicate that the virus spreading in the Americas is 89 identical to African genotypes but is most closely related to the Asian strain that circulated in French Polynesia during the 2013 2014 outbreak 33 34 35 The Asian strain appears to have first evolved around 1928 36 Transmission EditThe vertebrate hosts of the virus were primarily monkeys in a so called enzootic mosquito monkey mosquito cycle with only occasional transmission to humans Before the current pandemic began in 2007 Zika rarely caused recognized spillover infections in humans even in highly enzootic areas Infrequently however other arboviruses have become established as a human disease and spread in a mosquito human mosquito cycle like the yellow fever virus and the dengue fever virus both flaviviruses and the chikungunya virus a togavirus 37 Though the reason for the pandemic is unknown dengue a related arbovirus that infects the same species of mosquito vectors is known in particular to be intensified by urbanization and globalization 38 Zika is primarily spread by Aedes aegypti mosquitoes 39 and can also be transmitted through sexual contact 40 or blood transfusions 41 The basic reproduction number R0 a measure of transmissibility of Zika virus has been estimated to be between 1 4 and 6 6 42 In 2015 news reports drew attention to the rapid spread of Zika in Latin America and the Caribbean 43 At that time the Pan American Health Organization published a list of countries and territories that experienced local Zika virus transmission comprising Barbados Bolivia Brazil Colombia the Dominican Republic Ecuador El Salvador French Guiana Guadeloupe Guatemala Guyana Haiti Honduras Martinique Mexico Panama Paraguay Puerto Rico Saint Martin Suriname and Venezuela 44 45 46 By August 2016 more than 50 countries had experienced active local transmission of Zika virus 47 Mosquito Edit Global Aedes aegypti predicted distribution The map depicts the probability of occurrence blue none red highest occurrence Zika is primarily spread by the female Aedes aegypti mosquito which is active mostly in the daytime 48 49 The mosquitos must feed on blood to lay eggs 50 2 The virus has also been isolated from a number of arboreal mosquito species in the genus Aedes such as A africanus A apicoargenteus A furcifer A hensilli A luteocephalus and A vittatus with an extrinsic incubation period in mosquitoes around 10 days 24 The true extent of the vectors is still unknown Zika has been detected in many more species of Aedes along with Anopheles coustani Mansonia uniformis and Culex perfuscus although this alone does not incriminate them as vectors 49 To detect the presence of the virus usually requires genetic material to be analysed in a lab using the technique RT PCR A much cheaper and faster method involves shining a light at the head and thorax of the mosquito and detecting chemical compounds characteristic of the virus using near infrared spectroscopy 51 Transmission by A albopictus the tiger mosquito was reported from a 2007 urban outbreak in Gabon where it had newly invaded the country and become the primary vector for the concomitant chikungunya and dengue virus outbreaks 52 New outbreaks can occur if a person carrying the virus travels to another region where A albopictus is common 53 The potential societal risk of Zika can be delimited by the distribution of the mosquito species that transmit it The global distribution of the most cited carrier of Zika A aegypti is expanding due to global trade and travel 54 A aegypti distribution is now the most extensive ever recorded on parts of all continents except Antarctica including North America and even the European periphery Madeira the Netherlands and the northeastern Black Sea coast 55 A mosquito population capable of carrying Zika has been found in a Capitol Hill neighborhood of Washington DC and genetic evidence suggests they survived at least four consecutive winters in the region The study authors conclude that mosquitos are adapting for persistence in a northern climate 56 Zika virus appears to be contagious via mosquitoes for around a week after infection The virus is thought to be infectious for a longer period of time after infection at least 2 weeks when transmitted via semen 57 58 Research into its ecological niche suggests that Zika may be influenced to a greater degree by changes in precipitation and temperature than dengue making it more likely to be confined to tropical areas However rising global temperatures would allow for the disease vector to expand their range further north allowing Zika to follow 59 60 Production of sfRNA by Zika has been shown to be important for efficient virus transmission by A aegypti mosquitoes 61 Sexual Edit Zika can be transmitted from men and women to their sexual partners most known cases involve transmission from symptomatic men to women 40 62 63 As of April 2016 sexual transmission of Zika has been documented in six countries Argentina Australia France Italy New Zealand and the United States during the 2015 outbreak 14 ZIKV can persist in semen for several months with viral RNA detected up to one year 64 The virus replicates in the human testis where it infects several cell types including testicular macrophages peritubular cells and germ cells the spermatozoa precursors 65 Semen parameters can be altered in patients for several weeks post symptoms onset and spermatozoa can be infectious 66 Since October 2016 the CDC has advised men who have traveled to an area with Zika should use condoms or not have sex for at least six months after their return as the virus is still transmissible even if symptoms never develop 67 Pregnancy Edit Zika virus can spread by vertical or mother to child transmission during pregnancy or at delivery 12 68 An infection during pregnancy has been linked to changes in neuronal development of the unborn child 69 Severe progressions of infection have been linked to the development of microcephaly in the unborn child while mild infections potentially can lead to neurocognitive disorders later in life 70 71 72 Congenital brain abnormalities other than microcephaly have also been reported after a Zika outbreak 73 Studies in mice have suggested that maternal immunity to dengue virus may enhance fetal infection with Zika worsen the microcephaly phenotype and or enhance damage during pregnancy but it is unknown whether this occurs in humans 74 75 Blood transfusion Edit As of April 2016 update two cases of Zika transmission through blood transfusions have been reported globally both from Brazil 41 after which the US Food and Drug Administration FDA recommended screening blood donors and deferring high risk donors for 4 weeks 76 77 A potential risk had been suspected based on a blood donor screening study during the French Polynesian Zika outbreak in which 2 8 42 of donors from November 2013 and February 2014 tested positive for Zika RNA and were all asymptomatic at the time of blood donation Eleven of the positive donors reported symptoms of Zika fever after their donation but only three of 34 samples grew in culture 78 Pathogenesis EditZika virus replicates in the mosquito s midgut epithelial cells and then its salivary gland cells After 5 10 days the virus can be found in the mosquito s saliva If the mosquito s saliva is inoculated into human skin the virus can infect epidermal keratinocytes skin fibroblasts in the skin and the Langerhans cells The pathogenesis of the virus is hypothesized to continue with a spread to lymph nodes and the bloodstream 21 79 Flaviviruses replicate in the cytoplasm but Zika antigens have been found in infected cell nuclei 80 The viral protein numbered NS4A can lead to small head size microcephaly because it disrupts brain growth by hijacking a pathway which regulates growth of new neurons 81 In fruit flies both NS4A and the neighboring NS4B restrict eye growth 82 Zika fever EditMain article Zika fever Rash on an arm due to Zika Zika fever also known as Zika virus disease is an illness caused by Zika virus 83 Most cases have no symptoms but when present they are usually mild and can resemble dengue fever 83 84 Symptoms may include fever red eyes joint pain headache and a maculopapular rash 83 85 86 Symptoms generally last less than seven days 85 It has not caused any reported deaths during the initial infection 84 Infection during pregnancy causes microcephaly and other brain malformations in some babies 12 13 Infection in adults has been linked to Guillain Barre syndrome GBS and Zika virus has been shown to infect human Schwann cells 84 87 Diagnosis is by testing the blood urine or saliva for the presence of Zika virus RNA when the person is sick 83 85 In 2019 an improved diagnostic test based on research from Washington University in St Louis that detects Zika infection in serum was granted market authorization by the FDA 88 Prevention involves decreasing mosquito bites in areas where the disease occurs and proper use of condoms 85 89 Efforts to prevent bites include the use of DEET or picaridin based insect repellent covering much of the body with clothing mosquito nets and getting rid of standing water where mosquitoes reproduce 83 There is no vaccine 85 Health officials recommended that women in areas affected by the 2015 2016 Zika outbreak consider putting off pregnancy and that pregnant women not travel to these areas 85 90 While no specific treatment exists paracetamol acetaminophen and rest may help with the symptoms 85 Admission to a hospital is rarely necessary 84 Vaccine development Edit Main article Zika virus vaccine The World Health Organization has suggested that priority should be to develop inactivated vaccines and other nonlive vaccines which are safe to use in pregnant women 91 As of March 2016 update 18 companies and institutions were developing vaccines against Zika but they state a vaccine is unlikely to be widely available for about 10 years 91 92 In June 2016 the FDA granted the first approval for a human clinical trial for a Zika vaccine 93 In March 2017 a DNA vaccine was approved for phase 2 clinical trials This vaccine consists of a small circular piece of DNA known as a plasmid that expresses the genes for the Zika virus envelope proteins As the vaccine does not contain the full sequence of the virus it cannot cause infection 94 As of April 2017 both subunit and inactivated vaccines have entered clinical trials 95 History EditSee also Zika fever Epidemiology and Zika virus outbreak timeline Countries that have past or current evidence of Zika transmission as of January 2016 96 Spread of Zika 35 97 98 Spread of Zika in Africa and Asia based on molecular sequence data 22 Virus isolation in monkeys and mosquitoes 1947 Edit The virus was first isolated in April 1947 from a rhesus macaque monkey placed in a cage in the Ziika Forest of Uganda near Lake Victoria by the scientists of the Yellow Fever Research Institute 99 A second isolation from the mosquito A africanus followed at the same site in January 1948 100 When the monkey developed a fever researchers isolated from its serum a filterable transmissible agent which was named Zika in 1948 101 First evidence of human infection 1952 Edit Zika was first known to infect humans from the results of a serological survey in Uganda published in 1952 102 Of 99 human blood samples tested 6 1 had neutralizing antibodies As part of a 1954 outbreak investigation of jaundice suspected to be yellow fever researchers reported isolation of the virus from a patient 103 but the pathogen was later shown to be the closely related Spondweni virus 104 Spondweni was also determined to be the cause of a self inflicted infection in a researcher reported in 1956 105 Spread in equatorial Africa and to Asia 1951 2016 Edit Subsequent serological studies in several African and Asian countries indicated the virus had been widespread within human populations in these regions 101 The first true case of human infection was identified by Simpson in 1964 106 who was himself infected while isolating the virus from mosquitoes 101 From then until 2007 there were only 13 further confirmed human cases of Zika infection from Africa and Southeast Asia 107 A study published in 2017 showed that the Zika virus despite only a few cases were reported has been silently circulated in West Africa for the last two decades when blood samples collected between 1992 and 2016 were tested for the ZIKV IgM antibodies 108 Micronesia 2007 Edit Main article 2007 Yap Islands Zika virus outbreak In April 2007 the first outbreak outside of Africa and Asia occurred on the island of Yap in the Federated States of Micronesia characterized by rash conjunctivitis and arthralgia which was initially thought to be dengue chikungunya or Ross River disease 109 Serum samples from patients in the acute phase of illness contained RNA of Zika There were 49 confirmed cases 59 unconfirmed cases no hospitalizations and no deaths 110 2013 2014 Edit Main article 2013 2014 Zika virus outbreaks in Oceania After October 2013 Oceania s first outbreak showed an estimated 11 population infected for French Polynesia that also presented with Guillain Barre syndrome GBS The spread of ZIKV continued to New Caledonia Easter Island and the Cook Islands and where 1385 cases were confirmed by January 2014 During the same year Easter Island acknowledged 51 cases Australia began seeing cases in 2012 Research showed it was brought by travelers returning from Indonesia and other infected countries New Zealand also experienced infections rate increases through returning foreign travelers Oceania countries experiencing Zika today are New Caledonia Vanuatu Solomon Islands Marshall Islands American Samoa Samoa and Tonga 111 Between 2013 and 2014 further epidemics occurred in French Polynesia Easter Island the Cook Islands and New Caledonia 4 Americas 2015 present Edit Main article 2015 2016 Zika virus epidemic Image of a baby with microcephaly left compared to a normal baby right This is one of the potential effects of Zika virus Signs of microcephaly may develop a few months after birth There was an epidemic in 2015 and 2016 in the Americas The outbreak began in April 2015 in Brazil and spread to other countries in South America Central America North America and the Caribbean In January 2016 the WHO said the virus was likely to spread throughout most of the Americas by the end of the year 112 and in February 2016 the WHO declared the cluster of microcephaly and Guillain Barre syndrome cases reported in Brazil strongly suspected to be associated with the Zika outbreak a Public Health Emergency of International Concern 6 113 114 115 It was estimated that 1 5 million people were infected by Zika in Brazil 116 with over 3 500 cases of microcephaly reported between October 2015 and January 2016 117 A number of countries issued travel warnings and the outbreak was expected to significantly impact the tourism industry 6 118 Several countries have taken the unusual step of advising their citizens to delay pregnancy until more is known about the virus and its impact on fetal development 20 With the 2016 Summer Olympics hosted in Rio de Janeiro health officials worldwide voiced concerns over a potential crisis both in Brazil and when international athletes and tourists returned home and possibly would spread the virus Some researchers speculated that only one or two tourists might be infected during the three week period or approximately 3 2 infections per 100 000 tourists 119 In November 2016 the World Health Organization declared that Zika virus was no longer a global emergency while noting that the virus still represents a highly significant and a long term problem 120 As of August 2017 the number of new Zika virus cases in the Americas had fallen dramatically 121 India Edit On May 15 2017 three cases of Zika virus infection in India were reported in the state of Gujarat 122 123 By late 2018 there had been at least 159 cases in Rajasthan and 127 in Madhya Pradesh 124 In July 2021 the first case of Zika virus infection in the Indian state of Kerala was reported After the first confirmed case 19 other people who had previously presented symptoms were tested and 13 of those had positive results showing that Zika had been circulating in Kerala since at least May 2021 125 By August 6th 2021 there had been 65 reported cases in Kerala 126 In October 22 2021 an officer in the Indian Air Force in Kanpur tested positive for Zika virus making it the first reported case in the Indian state of Uttar Pradesh 127 Other cases Edit On 22 March 2016 Reuters reported that Zika was isolated from a 2014 blood sample of an elderly man in Chittagong in Bangladesh as part of a retrospective study 128 Zika is also occurring in Tanzania as of 2016 129 Between August and November 2016 455 cases of Zika virus infection were confirmed in Singapore 130 131 In 2017 Angola reported two cases of Zika fever 132 References Edit Goldsmith C 18 March 2005 TEM image of the Zika virus Centers for Disease Control and Prevention Retrieved 4 March 2016 Sirohi D Chen Z Sun L Klose T Pierson TC Rossmann MG Kuhn RJ April 2016 The 3 8 A resolution cryo EM structure of Zika virus Science 352 6284 467 470 Bibcode 2016Sci 352 467S doi 10 1126 science aaf5316 PMC 4845755 PMID 27033547 How to pronounce Zika HowToPronounce com a b Zika virus Emerging Infectious Diseases 20 6 1090 June 2014 doi 10 3201 eid2006 ET2006 PMC 4036762 PMID 24983096 a b c Malone RW Homan J Callahan MV Glasspool Malone J Damodaran L Schneider A et al March 2016 Zika Virus Medical Countermeasure Development Challenges PLOS Neglected Tropical Diseases 10 3 e0004530 doi 10 1371 journal pntd 0004530 PMC 4774925 PMID 26934531 a b c d Sikka V Chattu VK Popli RK Galwankar SC Kelkar D Sawicki SG Stawicki SP Papadimos TJ 11 February 2016 The Emergence of Zika Virus as a Global Health Security Threat A Review and a Consensus Statement of the INDUSEM Joint working Group JWG Journal of Global Infectious Diseases 8 1 3 15 doi 10 4103 0974 777X 176140 PMC 4785754 PMID 27013839 Mehrjardi MZ 1 January 2017 Is Zika Virus an Emerging TORCH Agent An Invited Commentary Virology 8 1178122X17708993 doi 10 1177 1178122X17708993 PMC 5439991 PMID 28579764 Symptoms Diagnosis amp Treatment Zika virus Atlanta Centers for Disease Control and Prevention 3 March 2016 Retrieved 4 March 2016 Abbink P Stephenson KE Barouch DH 19 June 2018 Zika virus vaccines Nature Reviews Microbiology 16 10 594 600 doi 10 1038 s41579 018 0039 7 PMC 6162149 PMID 29921914 Fernandez E Diamond MS 19 April 2017 Vaccination strategies against Zika virus Current Opinion in Virology 23 59 67 doi 10 1016 j coviro 2017 03 006 PMC 5576498 PMID 28432975 Zika Virus Vaccines NIH National Institute of Allergy and Infectious Diseases www niaid nih gov a b c Rasmussen SA Jamieson DJ Honein MA Petersen LR May 2016 Zika virus and birth defects Reviewing the Evidence for Causality The New England Journal of Medicine 374 20 1981 1987 doi 10 1056 NEJMsr1604338 PMID 27074377 S2CID 20675635 a b CDC concludes Zika causes microcephaly and other birth defects CDC 13 April 2016 Retrieved 14 April 2016 a b Zika virus microcephaly and Guillain Barre syndrome situation report PDF World Health Organization 7 April 2016 Retrieved 8 April 2016 Zika Virus in the Caribbean Travelers Health Travel Notices Centers for Disease Control and Prevention 15 January 2016 Petersen EE Staples JE Meaney Delman D Fischer M Ellington SR Callaghan WM Jamieson DJ January 2016 Interim Guidelines for Pregnant Women During a Zika Virus Outbreak United States 2016 MMWR Morbidity and Mortality Weekly Report 65 2 30 33 doi 10 15585 mmwr mm6502e1 PMID 26796813 Zika virus Advice for those planning to travel to outbreak areas ITV Report ITV News 22 January 2016 Retrieved 24 January 2016 a b Pregnant Irish women warned over Zika virus in central and South America RTE News 22 January 2016 Retrieved 23 January 2016 Zika Olympics plans announced by Rio authorities BBC News British Broadcasting Corporation 24 January 2016 Retrieved 24 January 2016 The Rio de Janeiro authorities have announced plans to prevent the spread of the Zika virus during the Olympic Games later this year The US Canada and EU health agencies have issued warnings saying pregnant women should avoid traveling to Brazil and other countries in the Americas which have registered cases of Zika a b Zika virus triggers pregnancy delay calls BBC News 23 January 2016 Retrieved 23 January 2016 a b Knipe DM Howley PM 2007 Fields Virology 5th ed Lippincott Williams amp Wilkins pp 1156 1199 ISBN 978 0 7817 6060 7 a b Faye O Freire CC Iamarino A Faye O de Oliveira JV Diallo M et al 9 January 2014 Molecular evolution of Zika virus during its emergence in the 20 th century PLOS Neglected Tropical Diseases 8 1 e2636 doi 10 1371 journal pntd 0002636 PMC 3888466 PMID 24421913 Cao Lormeau VM Roche C Teissier A Robin E Berry AL Mallet HP et al June 2014 Zika virus French polynesia South pacific 2013 Emerging Infectious Diseases 20 6 1085 1086 doi 10 3201 eid2006 140138 PMC 4036769 PMID 24856001 a b Hayes EB September 2009 Zika virus outside Africa Emerging Infectious Diseases 15 9 1347 1350 doi 10 3201 eid1509 090442 PMC 2819875 PMID 19788800 Kuno G Chang GJ 1 January 2007 Full length sequencing and genomic characterization of Bagaza Kedougou and Zika viruses Archives of Virology 152 4 687 696 doi 10 1007 s00705 006 0903 z PMID 17195954 Goodsell DS 2016 Zika Virus RCSB Protein Data Bank doi 10 2210 rcsb pdb mom 2016 5 Cox BD Stanton RA Schinazi RF August 2015 Predicting Zika virus structural biology Challenges and opportunities for intervention Antiviral Chemistry amp Chemotherapy 24 3 4 118 126 doi 10 1177 2040206616653873 PMC 5890524 PMID 27296393 Dai L Song J Lu X Deng YQ Musyoki AM Cheng H et al May 2016 Structures of the Zika Virus Envelope Protein and Its Complex with a Flavivirus Broadly Protective Antibody Cell Host amp Microbe 19 5 696 704 doi 10 1016 j chom 2016 04 013 PMID 27158114 ViralZone Zika virus strain Mr 766 viralzone expasy org SIB Swiss Institute of Bioinformatics Retrieved 24 August 2016 Pierson TC Diamond MS April 2012 Degrees of maturity the complex structure and biology of flaviviruses Current Opinion in Virology 2 2 168 175 doi 10 1016 j coviro 2012 02 011 PMC 3715965 PMID 22445964 Akiyama B Laurence H Massey A Costantino D Xie X Yang Y et al December 2016 Zika virus produces noncoding RNAs using a multi pseudoknot structure that confounds a cellular exonuclease Science 354 6316 1148 1152 doi 10 1126 science aah3963 PMID 27934765 Monel B Compton AA Bruel T Amraoui S Burlaud Gaillard J Roy N et al June 2017 Zika virus induces massive cytoplasmic vacuolization and paraptosis like death in infected cells The EMBO Journal 36 12 1653 1668 doi 10 15252 embj 201695597 PMC 5470047 PMID 28473450 a b Enfissi A Codrington J Roosblad J Kazanji M Rousset D January 2016 Zika virus genome from the Americas Lancet 387 10015 227 228 doi 10 1016 S0140 6736 16 00003 9 PMID 26775124 Zanluca C Melo VC Mosimann AL Santos GI Santos CN Luz K June 2015 First report of autochthonous transmission of Zika virus in Brazil Memorias do Instituto Oswaldo Cruz 110 4 569 572 doi 10 1590 0074 02760150192 PMC 4501423 PMID 26061233 a b Lanciotti RS Lambert AJ Holodniy M Saavedra S Signor L May 2016 Phylogeny of Zika Virus in Western Hemisphere 2015 Emerging Infectious Diseases 22 5 933 935 doi 10 3201 eid2205 160065 PMC 4861537 PMID 27088323 Ramaiah A Dai L Contreras D Sinha S Sun R Arumugaswami V July 2017 Comparative analysis of protein evolution in the genome of pre epidemic and epidemic Zika virus Infection Genetics and Evolution 51 74 85 doi 10 1016 j meegid 2017 03 012 PMID 28315476 Fauci AS Morens DM February 2016 Zika Virus in the Americas Yet Another Arbovirus Threat The New England Journal of Medicine 374 7 601 604 doi 10 1056 NEJMp1600297 PMID 26761185 S2CID 4377569 Gubler DJ December 2011 Dengue Urbanization and Globalization The Unholy Trinity of the 21 st Century Tropical Medicine and Health 39 4 Suppl 3 11 doi 10 2149 tmh 2011 S05 PMC 3317603 PMID 22500131 Zika virus found in common house mosquitoes in Brazil CNN 22 July 2016 Retrieved 23 July 2016 a b Oster AM Russell K Stryker JE Friedman A Kachur RE Petersen EE et al April 2016 Update Interim Guidance for Prevention of Sexual Transmission of Zika Virus United States 2016 MMWR Morbidity and Mortality Weekly Report 65 12 323 325 doi 10 15585 mmwr mm6512e3 PMID 27032078 a b Vasquez AM Sapiano MR Basavaraju SV Kuehnert MJ Rivera Garcia B April 2016 Survey of Blood Collection Centers and Implementation of Guidance for Prevention of Transfusion Transmitted Zika Virus Infection Puerto Rico 2016 MMWR Morbidity and Mortality Weekly Report 65 14 375 378 doi 10 15585 mmwr mm6514e1 PMID 27078190 Assessing the global threat from Zika virus Science Magazine 12 August 2016 Retrieved 15 August 2016 via www sciencemagazinedigital org Moloney A 22 January 2016 FACTBOX Zika virus spreads rapidly through Latin America Caribbean Thomson Reuters Foundation News Retrieved 26 January 2016 Mitchell C 18 January 2016 As the Zika virus spreads PAHO advises countries to monitor and report birth anomalies and other suspected complications of the virus Media Center Pan American Health Organization Retrieved 25 January 2016 Mitchell C 2 February 2016 PAHO Statement on Zika Virus Transmission and Prevention PAHO org Pan American Health Organization 5 things you need to know about Zika CNN 24 February 2016 Zika Virus All Countries amp Territories with Active Zika Virus Transmission Centers for Disease Control and Prevention Archived from the original on 21 September 2017 Retrieved 15 August 2016 Abushouk AI Negida A Ahmed H November 2016 An updated review of Zika virus Journal of Clinical Virology 84 53 58 doi 10 1016 j jcv 2016 09 012 PMID 27721110 a b Ayres CF March 2016 Identification of Zika virus vectors and implications for control The Lancet Infectious Diseases 16 3 278 279 doi 10 1016 S1473 3099 16 00073 6 PMID 26852727 Division of Vector Borne Diseases Dengue Branch Dengue and the Aedes aegypti mosquito PDF Centers for Disease Control and Prevention Retrieved 2 February 2012 Wishart S July August 2018 Shining a light on Zika New Zealand Geographic 152 25 Grard G Caron M Mombo IM Nkoghe D Mboui Ondo S Jiolle D Fontenille D Paupy C Leroy EM February 2014 Zika virus in Gabon Central Africa 2007 a new threat from Aedes albopictus PLOS Neglected Tropical Diseases 8 2 e2681 doi 10 1371 journal pntd 0002681 PMC 3916288 PMID 24516683 Zammarchi L Stella G Mantella A Bartolozzi D Tappe D Gunther S et al February 2015 Zika virus infections imported to Italy clinical immunological and virological findings and public health implications Journal of Clinical Virology 63 32 35 doi 10 1016 j jcv 2014 12 005 PMID 25600600 Kraemer MU Sinka ME Duda KA Mylne AQ Shearer FM Barker CM et al June 2015 The global distribution of the arbovirus vectors Aedes aegypti and Ae albopictus eLife 4 e08347 doi 10 7554 eLife 08347 PMC 4493616 PMID 26126267 Aedes aegypti Health Topics Vectors Mosquitos European Centre for Disease Protection and Control Retrieved 25 January 2016 Craig S Collins B 26 January 2016 Mosquitoes capable of carrying Zika virus found in Washington D C Notre Dame News University of Notre Dame Zika outbreak What you need to know BBC News Retrieved 31 July 2016 How to Avoid Mosquito Bites in Florida 10 June 2013 Retrieved 31 July 2016 Zika Virus Symptoms Transmission amp Solution SA News Channel S A NEWS 9 July 2021 Retrieved 10 July 2021 Carlson CJ Dougherty ER Getz W August 2016 An Ecological Assessment of the Pandemic Threat of Zika Virus PLOS Neglected Tropical Diseases 10 8 e0004968 doi 10 1371 journal pntd 0004968 PMC 5001720 PMID 27564232 Slonchak A Hugo L Freney M Hall Mendelin S Amarilla A Torres F Setoh Y Peng N Sng J Hall R van den Hurk A Devine G Khromykh May 2020 Zika virus noncoding RNA suppresses apoptosis and is required for virus transmission by mosquitoes Nature Communications 11 1 2205 Bibcode 2020NatCo 11 2205S doi 10 1038 s41467 020 16086 y PMC 7200751 PMID 32371874 Oussayef NL Pillai SK Honein MA Ben Beard C Bell B Boyle CA et al January 2017 Zika Virus 10 Public Health Achievements in 2016 and Future Priorities MMWR Morbidity and Mortality Weekly Report 65 52 1482 1488 doi 10 15585 mmwr mm6552e1 PMID 28056005 WHO chief going to the Olympics says Zika risk low Reuters 29 July 2016 According to Margaret Chan the director of the WHO Of course we also have learnt from the latest evidence it s not just infected men who can pass the disease to their sex partners There was a case of a lady passing the disease to a man so it can go both directions Le Tortorec A Matusali G Mahe D Aubry F Mazaud Guittot S Houzet L Dejucq Rainsford N July 2020 From Ancient to Emerging Infections The Odyssey of Viruses in the Male Genital Tract PDF Physiological Reviews 100 3 1349 1414 doi 10 1152 physrev 00021 2019 PMID 32031468 S2CID 211045539 Matusali G Houzet L Satie AP Mahe D Aubry F Couderc T et al October 2018 Zika virus infects human testicular tissue and germ cells The Journal of Clinical Investigation 128 10 4697 4710 doi 10 1172 JCI121735 PMC 6159993 PMID 30063220 Joguet G Mansuy JM Matusali G Hamdi S Walschaerts M Pavili L et al November 2017 Effect of acute Zika virus infection on sperm and virus clearance in body fluids a prospective observational study The Lancet Infectious Diseases 17 11 1200 1208 doi 10 1016 S1473 3099 17 30444 9 PMID 28838639 Petersen EE Meaney Delman D Neblett Fanfair R Havers F Oduyebo T Hills SL et al October 2016 Update Interim Guidance for Preconception Counseling and Prevention of Sexual Transmission of Zika Virus for Persons with Possible Zika Virus Exposure United States September 2016 MMWR Morbidity and Mortality Weekly Report 65 39 1077 1081 doi 10 15585 mmwr mm6539e1 PMID 27711033 CDC Zika Transmission Centers for Disease Control and Prevention 15 April 2016 Archived from the original on 20 September 2017 Retrieved 17 April 2016 Paploski IA Prates AP Cardoso CW Kikuti M Silva MM Waller LA et al August 2016 Time Lags between Exanthematous Illness Attributed to Zika Virus Guillain Barre Syndrome and Microcephaly Salvador Brazil Emerging Infectious Diseases 22 8 1438 1444 doi 10 3201 eid2208 160496 PMC 4982160 PMID 27144515 Aguilar Ticona Juan P Nery Nivison Ladines Lim Joseph B Gambrah Claudia Sacramento Gielson de Paula Freitas Bruno Bouzon Joseane Oliveira Filho Jamary Borja Ana Adhikarla Haritha Montoya Magelda 5 February 2021 Ramos Alberto Novaes ed Developmental outcomes in children exposed to Zika virus in utero from a Brazilian urban slum cohort study PLOS Neglected Tropical Diseases 15 2 e0009162 doi 10 1371 journal pntd 0009162 ISSN 1935 2735 PMC 7891708 PMID 33544730 Rubin EJ Greene MF Baden LR March 2016 Zika Virus and Microcephaly The New England Journal of Medicine 374 10 984 985 doi 10 1056 NEJMe1601862 PMID 26862812 S2CID 205079825 Stanelle Bertram S Walendy Gnirss K Speiseder T Thiele S Asante IA Dreier C et al October 2018 Male offspring born to mildly ZIKV infected mice are at risk of developing neurocognitive disorders in adulthood Nature Microbiology 3 10 1161 1174 doi 10 1038 s41564 018 0236 1 hdl 10138 306618 PMID 30202017 S2CID 52181681 Kikuti M Cardoso CW Prates AP Paploski IA Kitron U Reis MG et al November 2018 Congenital brain abnormalities during a Zika virus epidemic in Salvador Brazil April 2015 to July 2016 Euro Surveillance 23 45 1 10 doi 10 2807 1560 7917 ES 2018 23 45 1700757 PMC 6234531 PMID 30424827 Rathore AP Saron WA Lim T Jahan N St John AL February 2019 Maternal immunity and antibodies to dengue virus promote infection and Zika virus induced microcephaly in fetuses Science Advances 5 2 eaav3208 Bibcode 2019SciA 5 3208R doi 10 1126 sciadv aav3208 PMC 6392794 PMID 30820456 Brown JA Singh G Acklin JA Lee S Duehr JE Chokola AN et al January 2019 Dengue Virus Immunity Increases Zika Virus Induced Damage during Pregnancy Immunity 50 3 751 762 e5 doi 10 1016 j immuni 2019 01 005 PMC 6947917 PMID 30737148 Recommendations for Donor Screening Deferral and Product Management to Reduce the Risk of Transfusion Transmission of Zika Virus PDF Food and Drug Administration February 2016 Zika virus infection outbreak Brazil and the Pacific region PDF Rapid Risk Assessments Stockholm European Centre for Disease Prevention and Control 25 May 2015 pp 4 5 Archived from the original PDF on 13 October 2015 Retrieved 12 February 2016 Musso D Nhan T Robin E Roche C Bierlaire D Zisou K et al April 2014 Potential for Zika virus transmission through blood transfusion demonstrated during an outbreak in French Polynesia November 2013 to February 2014 Euro Surveillance 19 14 20761 doi 10 2807 1560 7917 es2014 19 14 20761 PMID 24739982 Chan JF Choi GK Yip CC Cheng VC Yuen KY May 2016 Zika fever and congenital Zika syndrome An unexpected emerging arboviral disease The Journal of Infection 72 5 507 524 doi 10 1016 j jinf 2016 02 011 hdl 10722 231183 PMC 7112603 PMID 26940504 Buckley A Gould EA August 1988 Detection of virus specific antigen in the nuclei or nucleoli of cells infected with Zika or Langat virus The Journal of General Virology 69 8 1913 1920 doi 10 1099 0022 1317 69 8 1913 PMID 2841406 Molly Chiu 14 November 2019 How maternal Zika virus infection results in newborn microcephaly ScienMag Retrieved 17 November 2019 Harsh S Fu Y Kenney E Han Z Eleftherianos I April 2020 Drosophila through regulation of JAK STAT signaling Disease Models amp Mechanisms 13 4 dmm040816 doi 10 1242 dmm 040816 PMC 7197722 PMID 32152180 a b c d e Zika virus World Health Organization January 2016 Retrieved 3 February 2016 a b c d Factsheet for health professionals Health topics Zika virus infection European Centre for Disease Prevention and Control Retrieved 22 December 2015 a b c d e f g Chen LH Hamer DH May 2016 Zika Virus Rapid Spread in the Western Hemisphere Annals of Internal Medicine 164 9 613 615 doi 10 7326 M16 0150 PMID 26832396 Musso D Nilles EJ Cao Lormeau VM October 2014 Rapid spread of emerging Zika virus in the Pacific area Clinical Microbiology and Infection 20 10 O595 6 doi 10 1111 1469 0691 12707 PMID 24909208 Dhiman G Abraham R Griffin DE July 2019 Human Schwann cells are susceptible to infection with Zika and yellow fever viruses but not dengue virus Scientific Reports 9 1 9951 Bibcode 2019NatSR 9 9951D doi 10 1038 s41598 019 46389 0 PMC 6616448 PMID 31289325 Zika diagnostic test granted market authorization by FDA Washington University School of Medicine in St Louis 3 September 2019 Retrieved 14 February 2020 Oster AM Russell K Stryker JE Friedman A Kachur RE Petersen EE et al April 2016 Update Interim Guidance for Prevention of Sexual Transmission of Zika Virus United States 2016 MMWR Morbidity and Mortality Weekly Report 65 12 323 325 doi 10 15585 mmwr mm6512e3 PMID 27032078 Brazil warns against pregnancy due to spreading virus CNN 24 December 2015 Retrieved 24 December 2015 a b WHO and experts prioritize vaccines diagnostics and innovative vector control tools for Zika R amp D World Health Organization 9 March 2016 Retrieved 13 March 2016 Cook J 27 January 2016 Zika virus US scientists say vaccine 10 years away BBC News Retrieved 28 January 2016 Sagonowsky E 21 June 2016 Inovio set for first Zika vaccine human trial fiercepharma com Retrieved 1 July 2016 Phase 2 Zika vaccine trial begins in U S Central and South America National Institutes of Health NIH 31 March 2017 Fernandez E Diamond MS April 2017 Vaccination strategies against Zika virus Current Opinion in Virology 23 59 67 doi 10 1016 j coviro 2017 03 006 PMC 5576498 PMID 28432975 Geographic Distribution Zika Virus Centers for Disease Control and Prevention 5 November 2014 Retrieved 18 January 2016 Gatherer D Kohl A February 2016 Zika virus a previously slow pandemic spreads rapidly through the Americas PDF The Journal of General Virology 97 2 269 273 doi 10 1099 jgv 0 000381 PMID 26684466 Zika virus in the United States Centers for Disease Control and Prevention Archived from the original on 20 February 2016 Retrieved 20 February 2016 Cohen J 8 February 2016 Zika s long strange trip into the limelight Science American Association for the Advancement of Science Retrieved 10 February 2016 Haddow AD Schuh AJ Yasuda CY Kasper MR Heang V Huy R et al 2012 Genetic characterization of Zika virus strains geographic expansion of the Asian lineage PLOS Neglected Tropical Diseases 6 2 e1477 doi 10 1371 journal pntd 0001477 PMC 3289602 PMID 22389730 a b c Wikan N Smith DR July 2016 Zika virus history of a newly emerging arbovirus The Lancet Infectious Diseases 16 7 e119 e126 doi 10 1016 s1473 3099 16 30010 x PMID 27282424 Dick GW September 1952 Zika virus II Pathogenicity and physical properties Transactions of the Royal Society of Tropical Medicine and Hygiene 46 5 521 534 doi 10 1016 0035 9203 52 90043 6 PMID 12995441 Macnamara FN March 1954 Zika virus A report on three cases of human infection during an epidemic of jaundice in Nigeria Transactions of the Royal Society of Tropical Medicine and Hygiene 48 2 139 145 doi 10 1016 0035 9203 54 90006 1 PMID 13157159 Wikan N Smith DR January 2017 First published report of Zika virus infection in people Simpson not MacNamara The Lancet Infectious Diseases 17 1 15 17 doi 10 1016 S1473 3099 16 30525 4 PMID 27998553 Bearcroft WG September 1956 Zika virus infection experimentally induced in a human volunteer Transactions of the Royal Society of Tropical Medicine and Hygiene 50 5 442 448 doi 10 1016 0035 9203 56 90091 8 PMID 13380987 Simpson DI July 1964 Zika virus infection in man Transactions of the Royal Society of Tropical Medicine and Hygiene 58 4 335 338 doi 10 1016 0035 9203 64 90201 9 PMID 14175744 Ramzy Austin 10 February 2016 Experts Study Zika s Path From First Outbreak in Pacific The New York Times Hong Kong Retrieved 12 February 2016 Henry Martha 24 May 2017 Zika virus found to be circulating in Africa for decades Harvard T H Chan School of Public Health Retrieved 5 June 2017 Altman LK 3 July 2007 Little Known Virus Challenges a Far Flung Health System The New York Times Duffy MR Chen TH Hancock WT Powers AM Kool JL Lanciotti RS et al June 2009 Zika virus outbreak on Yap Island Federated States of Micronesia The New England Journal of Medicine 360 24 2536 2543 doi 10 1056 NEJMoa0805715 PMID 19516034 Saiz JC Vazquez Calvo A Blazquez AB Merino Ramos T Escribano Romero E Martin Acebes MA 19 April 2016 Zika Virus the Latest Newcomer Frontiers in Microbiology 7 496 doi 10 3389 fmicb 2016 00496 PMC 4835484 PMID 27148186 WHO sees Zika outbreak spreading through the Americas Reuters 25 January 2016 Retrieved 25 January 2016 WHO Director General summarizes the outcome of the Emergency Committee regarding clusters of microcephaly and Guillain Barre syndrome World Health Organization 1 February 2016 Retrieved 2 February 2016 Roberts M 1 February 2016 Zika linked condition WHO declares global emergency BBC News Retrieved 1 February 2016 Pearson Michael 2 February 2016 Zika virus sparks public health emergency CNN Retrieved 2 February 2016 Boadle A Brown T Orr B 18 February 2016 U S Brazil researchers join forces to battle Zika virus Reuters Brasilia Retrieved 4 March 2016 Microcephaly in Brazil potentially linked to the Zika virus epidemic ECDC assesses the risk News and Media European Centre for Disease Prevention and Control 25 November 2015 Retrieved 18 January 2016 Kiernan P Jelmayer R 3 February 2016 Zika Fears Imperil Brazil s Tourism Push The Wall Street Journal Retrieved 27 February 2016 Belluz J 26 May 2016 Rio Olympics 2016 why athletes and fans aren t likely to catch Zika Vox Retrieved 1 June 2016 World Health Organization declares end of Zika emergency The Irish Times Retrieved 18 November 2016 Cohen J 16 August 2017 Zika has all but disappeared in the Americas Why Science doi 10 1126 science aao6984 2017 India World Health Organization 26 May 2017 Retrieved 26 October 2021 Bhardwaj Sumit Gokhale Mangesh D Mourya Devendra T November 2017 Zika virus Current concerns in India Indian Journal of Medical Research 146 5 572 575 doi 10 4103 ijmr IJMR 1160 17 inactive 4 November 2021 PMC 5861468 PMID 29512599 CS1 maint DOI inactive as of November 2021 link Rolph Michael S Mahalingam Suresh 1 May 2019 Zika s passage to India The Lancet Infectious Diseases 19 5 469 470 doi 10 1016 S1473 3099 19 30169 0 PMID 31034391 S2CID 140302216 Zika Virus Disease India World Health Organization 14 October 2021 Retrieved 26 October 2021 65 Zika virus cases reported in Kerala as on August 2 2021 Health minister Mansukh Mandaviya The Economic Times 6 August 2021 Retrieved 26 October 2021 Singh Ranjal 24 October 2021 Zika virus case detected in Kanpur first in Uttar Pradesh India Today Retrieved 26 October 2021 Bangladesh Confirms First Case of Zika Virus Newsweek 22 March 2016 Retrieved 22 March 2016 Blood samples show presence of Zika virus in Tanzania Anadolu Agency Retrieved 19 December 2016 Ho ZJ Hapuarachchi HC Barkham T Chow A Ng LC Lee JM et al Singapore Zika Study Group August 2017 Outbreak of Zika virus infection in Singapore An epidemiological entomological virological and clinical analysis The Lancet Infectious Diseases 17 8 813 821 doi 10 1016 S1473 3099 17 30249 9 PMID 28527892 Zika Virus in Singapore CDC Retrieved 3 September 2016 Angola reports first two cases of Zika virus Reuters 11 January 2017 Retrieved 18 January 2017 This article incorporates public domain material from websites or documents of the Centers for Disease Control and Prevention External links EditWikimedia Commons has media related to Zika virus Scholia has a topic profile for Zika virus Wikiquote has quotations related to Zika virus Zika virus Centers for Disease Control and Prevention 5 November 2014 Zika virus Fact sheet World Health Organization Zika virus illustrations 3D model and animation visual science com Zika virus strain Mr 766 Viral Zone Schmaljohn AL McClain D 1996 54 Alphaviruses Togaviridae and Flaviviruses Flaviviridae In Baron S ed Medical Microbiology 4th ed ISBN 978 0 9631172 1 2 PMID 21413253 NBK7633 Animation on Zika YouTube Scientific Animations without Borders and the World Health Organization WHO Schuchat Anne 15 October 2018 Zika Virus 101 YouTube Centers for Disease Control and Prevention CDC Retrieved from https en wikipedia org w index php title Zika virus amp oldid 1054468363, wikipedia, wiki, book,

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